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UCD Biochemical Engineering Professor Mohamed Al-Rubeai has published a new book: Animal Cell Culture.

The book, published by Springer, is available now at Springer.com and amazon.co.uk
​Animal cells are the preferred “cell factories” for the production of complex molecules and antibodies for use as prophylactics, therapeutics or diagnostics. Animal cells are required for the correct post-translational processing (including glycosylation) of biopharmaceutical protein products. They are used for the production of viral vectors for gene therapy. Major targets for this therapy include cancer, HIV, arthritis, cardiovascular and CNS diseases and cystic fibrosis. Animal cells are used as in vitro substrates in pharmacological and toxicological studies. This book is designed to serve as a comprehensive review of animal cell culture, covering the current status of both research and applications. For the student or R&D scientist or new researcher the protocols are central to the performance of cell culture work, yet a broad understanding is essential for translation of laboratory findings into the industrial production. Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field to produce state-of-the-art collection of current research. A major reference volume on cell culture research and how it impacts on production of biopharmaceutical proteins worldwide, the book is essential reading for everyone working in cell culture and is a recommended volume for all biotechnology libraries.

Please see the link below which covers the visit and to learn about some of the pioneering programs that are underway at the Biomanufacturing Education and Training Centre (BETC):

http://wp.wpi.edu/dailyherd/2015/01/09/governor-tours-betc/#top

Click the link below to open the PDF

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Flow Dynamics of pebble bed reactors for next generation Nuclear Energy:

Led by Dr. Muthanna Al-Dahhan, chair and professor of chemical and biochemical engineering and professor of nuclear engineering, Missouri S&T is developing new approaches to understanding how nuclear fuel pebbles would behave in what are called “fourth generation” pebble-bed nuclear reactors and how gas dynamics can effectively take the generated heat. These reactors would house uranium fuel in spheres the size of tennis balls (the “pebbles”) rather than rods, and the cores would cooled by helium gas instead of water. These reactors also are considered to be more efficient than water-cooled reactors and would operate at much higher temperatures.
Al-Dahhan is combining a broad array of approaches to measurement, but they fall into two categories:

• Techniques that are based on radioisotopes for imaging and visualization of opage multiphase flow systems which have been used to measure and track nuclear fuel pebbles and imaging the reactor structure of pebble bed reactors in addition to other types of multiphase reactors and flow systems. A radioisotope is the atom of a chemical that has an unstable nucleus and emits radiation as it decays.
• Sophisticated techniques to measure various hydrodynamics, heat, mass and kinetics parameters of multiphase reactors and flow systems. Some of these have been used to measure gas dynamics and heat transfer in pebble bed reactors.

“These techniques can show us what is going on inside the reactor and can be used to advance their knowledge and understanding,” says Al-Dahhan. “All of this is related to the design, operation, risk assessment and analysis of future pebble-bed reactors and other types of multiphase reactors and flow systems in general.”

Augmenting these techniques with sophisticated mathematical algorithms, Al-Dahhan creates computer-simulated visualizations that could help engineers plan future nuclear reactors. Using what he calls “gamma ray tomography and radioactive particle tracking,” Al-Dahhan is able to view what is going on inside a reactor core, in much the same way that a physician uses ultrasound equipment to view movement within the human body.
“We can visualize the reactor core and the dynamics of how the nuclear fuel particles behave,” Al-Dahhan says. From that data – and via computational fluid dynamics – Al-Dahhan can create models that predict how nuclear fuel pebbles would behave in a pebble-bed nuclear reactor, and how the helium would disperse heat through the process.

Using these measurement techniques could help the nuclear industry set benchmarks for determining how to build fourth-generation reactors, Al-Dahhan says. He adds that the techniques can also be used to set benchmarks for other energy-related projects, such as the design of conventional energy and chemical processes, coal/biomass gasification plants, bioenergy processes, waste treatment processes or conventional nuclear plants including small modular nuclear reactors (SMRs).

In September 2012, Al-Dahhan presented his research at a conference in Cargese, Corsica, France, sponsored by Polytechnique Montreal, French nuclear research institutes, and several European universities and agencies. His presentation was titled “Benchmarking Multiphase CFD (Computational Fluid Dynamics) Results via Sophisticated Experimental Measurement Techniques and Methodologies.”

While China and South Africa have started building small versions of pebble-bed reactors, the United States has yet to move forward with constructing such plants. In Missouri, Westinghouse Electric Co. announced last October that it would work with Missouri S&T, the University of Missouri-Columbia and the University of Missouri System to explore the feasibility of developing small modular nuclear reactors in the state. The effort also involves Ameren Missouri, which operates Missouri’s only nuclear power plant, the Callaway Energy Center.

In addition to leading the chemical and biochemical engineering department, Al-Dahhan is a member of Missouri S&T’s nuclear engineering faculty. The nuclear engineering department also manages S&T’s teaching reactor, which was the first built in Missouri, constructed in 1961. The University of Missouri-Columbia also has a nuclear reactor.